HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 4-{[(5-oxo-1-pyridazin-3-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-(3,4,5-trimethoxyphenyl)methyl]amino}benzamidine acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | 2-Hydrazinylpyrimidine | HCID 346558 | — |
| Reactant | 3-Hydrazinylpyridazine hydrochloride | HCID 21455992 | — |
| Reactant | {2-(3-Hydroxy-4,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester | HCID 72312728 | — |
| Reactant | {2-(3-Hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester | HCID 72312820 | — |
| Product | 4-{[(5-oxo-1-pyridazin-3-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-(3,4,5-trimethoxyphenyl)methyl]amino}benzamidine acetate | HCID 136366230 | — |
Reaction Steps
The same procedure was carried out as in Example (6a), except that {2-(3-hydroxy-4,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester, methyl iodide and 3-hydrazinopyridazine hydrochloride were used instead of respectively the {2-(3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester, 1-bromo-2-methoxyethane and 2-hydrazinopyrimidine, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816522B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-34cd22955b74425887557d3b6450ec10 |
| Source note | uspto-grants-2010_10 |