HRID1161474

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

HCID80972

Ethane, 1-bromo-2-methoxy-

C3H7BrO

HCID346558

2-hydrazinopyrimidine

C4H6N4

HCID21455992

3-Hydrazinylpyridazine--hydrogen chloride (1/1)

C4H7ClN4

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(O)c(OC)c(OC)c1

HCID72312728

未命名化合物

结构：COC(=O)N=C(SC)C(=Nc1ccc(-c2noc(C)n2)cc1)c1cc(O)cc(OC)c1

HCID72312820

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.COc1cc(C(Nc2ccc(C(=N)N)cc2)c2nn(-c3cccnn3)c(=O)[nH]2)cc(OC)c1OC

HCID136366230

未命名化合物

PROCEDURE

实验过程

The same procedure was carried out as in Example (6a), except that {2-(3-hydroxy-4,5-dimethoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester, methyl iodide and 3-hydrazinopyridazine hydrochloride were used instead of respectively the {2-(3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene}carbamic acid methyl ester, 1-bromo-2-methoxyethane and 2-hydrazinopyrimidine, to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-34cd22955b74425887557d3b6450ec10
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07816522B2
来源说明: uspto-grants-2010_10

反应 SMILES

C[O:2][C:3](=O)[N:4]=[C:5](SC)[C:6]([C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([OH:30])[CH:21]=1)=[N:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:18]=C(C)O[N:15]=2)=[CH:10][CH:9]=1.CI.Cl.[NH:37]([C:39]1[N:40]=[N:41][CH:42]=[CH:43][CH:44]=1)[NH2:38].[CH3:45][O:46]C(=O)N=C(SC)C(C1C=C(OC)C=C(O)C=1)=NC1C=CC(C2N=C(C)ON=2)=CC=1.BrCCOC.N(C1N=CC=CN=1)N>>[C:24]([OH:26])(=[O:46])[CH3:25].[O:2]=[C:3]1[N:37]([C:39]2[N:40]=[N:41][CH:42]=[CH:43][CH:44]=2)[N:38]=[C:5]([CH:6]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH2:18])=[NH:15])=[CH:10][CH:9]=2)[C:20]2[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:45])[CH:21]=2)[NH:4]1