反应详情

温度

60 °C

To a solution of 0.152 g of 5-(3-{(2-fluoro-4,5-dimethoxyphenyl)-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]methyl}-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl)-1H-pyrazole-4-carboxylic acid ethyl ester in 15 ml of a methanol:water:acetic acid=1:1:1 mixed solvent there was added 0.150 g of iron powder, and the mixture was heated and stirred at 60° C. for 20 hours. After filtering the reaction mixture, it was purified by reverse-phase high performance liquid chromatography (acetonitrile-water, 0.1% acetic acid) to give 0.091 g of the title compound.

1. temperaturethe mixture was heated
2. filtrationAfter filtering the reaction mixture, it
3. customwas purified by reverse-phase high performance liquid chromatography (acetonitrile-water, 0.1% acetic acid)