反应详情

After adding 45.2 g of 4-amino-2-methylsulfanylthiazole-5-carboxylic acid methyl ester [CAS No. 60093-05-2] to 2 liters of a water:methanol=1:1 mixed solvent at room temperature, 408 g of Oxone was added in small portions over a period of 30 minutes with stirring. The mixture was stirred at room temperature for 24 hours, and then poured into a mixture of 10 liters of ethyl acetate and 10 liters of water. After washing the organic layer with 5 liters of saturated brine, it was dried over anhydrous magnesium sulfate. The desiccating agent was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (37.6 g) as a white solid.

1. stirringThe mixture was stirred at room temperature for 24 hours
2. washAfter washing the organic layer with 5 liters of saturated brine, it
3. dry with materialwas dried over anhydrous magnesium sulfate
4. filtrationThe desiccating agent was filtered off
5. concentrationthe filtrate was concentrated under reduced pressure