HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1161522Generated: October 28, 2026
Triethylamine → 3-{3-[(4-Cyanophenylamino)-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)methyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}thiophene-2-carboxylic acid methyl ester
https://huagongshe.com/reaction/1161522
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 3-Hydrazinothiophene-2-Carboxylate | HCID 2777595 | — |
| Reactant | [2-(4-Cyanophenylimino)-2-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)-1-methylsulfanylethylidene]carbamic acid methyl ester | HCID 72312729 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-{3-[(4-Cyanophenylamino)-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)methyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}thiophene-2-carboxylic acid methyl ester | HCID 135982145 | — |
Reaction Steps
To a solution of 2 g of [2-(4-cyanophenylimino)-2-(5-fluoro-8-methoxy-2,3-dihydrobenzo[1,4]dioxin-6-yl)-1-methylsulfanylethylidene]carbamic acid methyl ester in 24 ml of DMF there were added 720 mg of 3-hydrazinothiophene-2-carboxylic acid methyl ester and 1.2 ml of triethylamine, and the mixture was stirred overnight at 85° C. under a nitrogen atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07816522B2 |
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| Source dataset | uspto-grants-2010_10 |
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| ORD ID | ord-2add5429012d490880aaba2b35747f4c |
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| Source note | uspto-grants-2010_10 |
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