2-Pyridone hydrazone dihydrochloride → (S)-4-{[(8-Methoxy-4H-benzo[1,3]dioxin-6-yl)-(5-oxo-1-pyridin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}benzamidine acetate

HRID 1161576Notes

Reaction equation

HRID 1161576 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:5][O:6][C:7]1[C:16]2[O:15][CH2:14][O:13][CH2:12][C:11]=2[CH:10]=[C:9]([C@H:17]([NH:30][C:31]2[CH:39]=[CH:38][C:34]([C:35]([NH2:37])=[NH:36])=[CH:33][CH:32]=2)[C:18]2[NH:22][C:21](=[O:23])[N:20]([C:24]3N=[CH:28][CH:27]=[CH:26][N:25]=3)[N:19]=2)[CH:8]=1.Cl.Cl.N([C:44]1C=CC=CN=1)N>>[C:1]([OH:4])(=[O:3])[CH3:2].[CH3:5][O:6][C:7]1[C:16]2[O:15][CH2:14][O:13][CH2:12][C:11]=2[CH:10]=[C:9]([C@H:17]([NH:30][C:31]2[CH:39]=[CH:38][C:34]([C:35]([NH2:37])=[NH:36])=[CH:33][CH:32]=2)[C:18]2[NH:22][C:21](=[O:23])[N:20]([C:24]3[CH:44]=[CH:28][CH:27]=[CH:26][N:25]=3)[N:19]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 64543982-Pyridone hydrazone dihydrochlorideHCID 136366222(S)-4-{[(8-methoxy-4H-benzo[1,3]dioxin-6-yl)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}benzamidine acetate

Product 1

HCID 136389289(S)-4-{[(8-Methoxy-4H-benzo[1,3]dioxin-6-yl)-(5-oxo-1-pyridin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}benzamidine acetate

Procedure

The same procedure was carried out as in Examples (21i) to (21k), except that 2-hydrazinopyridine dihydrochloride was used instead of 2-hydrazinopyrimidine in Example (21i), to give the first eluting enantiomer of the title compound.

Sources & evidence

ORD record
ord-b341856b902f401f98b626e3a2531f5f
Source dataset
uspto-grants-2010_10
Patent number
US07816522B2

Reaction notes

Loading…