HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridone hydrazone dihydrochloride → (S)-4-{[(8-Methoxy-4H-benzo[1,3]dioxin-6-yl)-(5-oxo-1-pyridin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}benzamidine acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridone hydrazone dihydrochloride | HCID 6454398 | — |
| Reactant | (S)-4-{[(8-methoxy-4H-benzo[1,3]dioxin-6-yl)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}benzamidine acetate | HCID 136366222 | — |
| Product | (S)-4-{[(8-Methoxy-4H-benzo[1,3]dioxin-6-yl)-(5-oxo-1-pyridin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}benzamidine acetate | HCID 136389289 | — |
Reaction Steps
The same procedure was carried out as in Examples (21i) to (21k), except that 2-hydrazinopyridine dihydrochloride was used instead of 2-hydrazinopyrimidine in Example (21i), to give the first eluting enantiomer of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07816522B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-b341856b902f401f98b626e3a2531f5f |
| Source note | uspto-grants-2010_10 |