HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorothiophenol → 4-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorothiophenol | HCID 67789 | — |
| Reactant | 2-Amino-4-chloro-6-phenylpyrimidine | HCID 240802 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamine | HCID 58626152 | 64% |
Reaction Steps
4-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamine was prepared from 4-Chloro-6-phenyl-pyrimidin-2-ylamine (0.5 g, 2.44 mmol) using 4-fluorothiophenol (0.31 mg, 2.44 mmol) in iso-propanol (15 mL) at 80° C. for 6 hours. Yield: 64%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820654B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-9dbfbefc1a424b52ae2bae71432d0025 |
| Source note | uspto-grants-2010_10 |