4-Fluorothiophenol → 4-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamine

HRID 1161658Notes

Reaction equation

HRID 1161658 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([NH2:14])[N:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([SH:22])=[CH:18][CH:17]=1>C(O)(C)C>[F:15][C:16]1[CH:21]=[CH:20][C:19]([S:22][C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:5]=[C:4]([NH2:14])[N:3]=2)=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 677894-FluorothiophenolHCID 2408022-Amino-4-chloro-6-phenylpyrimidine

Product 1

HCID 586261524-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamineYield 64%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamine was prepared from 4-Chloro-6-phenyl-pyrimidin-2-ylamine (0.5 g, 2.44 mmol) using 4-fluorothiophenol (0.31 mg, 2.44 mmol) in iso-propanol (15 mL) at 80° C. for 6 hours. Yield: 64%.

Workup

  1. customat 80° C.
  2. customfor 6 hours

Sources & evidence

ORD record
ord-9dbfbefc1a424b52ae2bae71432d0025
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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