Hydrogen Bromide → HCID 178518019, compound

HRID 1161659Notes

Reaction equation

HRID 1161659 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:13](SCC)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.Br.[OH2:27]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:13]([OH:27])[N:12]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 58626095HCID 58626095, compound

Product 1

HCID 178518019HCID 178518019, compound

Conditions

Temperature
30 °C

Procedure

A mixture of compound (3-chloro-4-methoxyphenyl)-(2-ethylsulfanyl-6-phenylpyrimidin-4-yl)amine and 47% hydrobromic acid solution in water (10 mL) was stirred at refluxing temperature for 12 hours. The reaction mixture was cooled to temperature in the range of 20-40° C. and excess of acid was removed under vacuum. The mixture was then neutralized with ammonia solution. The solid thus obtained was filtered off and dried under vacuum to afford the title compound as a pale brown color solid.

Workup

  1. temperatureat refluxing temperature for 12 hours
  2. customwas removed under vacuum
  3. customThe solid thus obtained
  4. filtrationwas filtered off
  5. customdried under vacuum

Sources & evidence

ORD record
ord-43fee19cf53f4f97b3e9aa15414b0523
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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