Urea → HCID 178515561, compound

HRID 1161663Notes

Reaction equation

HRID 1161663 reaction equation
C(O[C:4](=[O:14])[CH2:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.[NH2:15][C:16]([NH2:18])=[O:17]>C(O)C>[C:7]1([C:6]2[N:18]=[C:16]([OH:17])[N:15]=[C:4]([OH:14])[CH:5]=2)[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 7170Ethyl benzoylacetate

Product 1

HCID 178515561HCID 178515561, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
30 °C

Procedure

A mixture of 3-oxo-3-phenylpropionic acid ethyl ester (20 g, 104.05 mmol) and urea (6.24 g, 104.05 mmol) was reacted in a microwave irradiation for 3 minutes. The mixture was cooled to temperature in the range of 20-40° C. and diluted with ethyl alcohol (100 mL). The solid precipitated was filtered, washed with hexane (2×20 mL) to afford the desired compound as a yellow solid.

Workup

  1. customwas reacted in a microwave irradiation for 3 minutes
  2. customThe solid precipitated
  3. filtrationwas filtered
  4. washwashed with hexane (2×20 mL)

Sources & evidence

ORD record
ord-16f63012c8884e35a4f7df988756c0bb
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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