4-amino-N-methylbenzene-1-sulfonamide → 4-[4-(4-hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide

HRID 1161668Notes

Reaction equation

HRID 1161668 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]2)[CH:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([NH:31][CH3:32])(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[OH:14][CH:11]1[CH2:12][CH2:13][N:8]([C:6]2[CH:5]=[C:4]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:3]=[C:2]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([S:28]([NH:31][CH3:32])(=[O:30])=[O:29])=[CH:24][CH:23]=3)[N:7]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 743684-amino-N-methylbenzene-1-sulfonamideHCID 58626078HCID 58626078, compound

Product 1

HCID 116765324-[4-(4-hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide

Procedure

A sample of 4-[4-(4-hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide was prepared from compound 1-(2-chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol (0.5 g, 1.74 mmol) and 4-amino-N-methyl-benzenesulfonamide (0.39 g, 1.74 mmol) according to a procedure analogous to that described above in Example 48.

Sources & evidence

ORD record
ord-0c857fc085c34bc5b6e0b9e23f6296de
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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