p-Aminoacetophenone → HCID 11517478, compound

HRID 1161669Notes

Reaction equation

HRID 1161669 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]2)[CH:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH3:29])=[CH:24][CH:23]=1>>[ClH:1].[OH:14][CH:11]1[CH2:12][CH2:13][N:8]([C:6]2[CH:5]=[C:4]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:3]=[C:2]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[O:30])[CH3:29])=[CH:24][CH:23]=3)[N:7]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 7468p-AminoacetophenoneHCID 586260781-(2-Chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol

Product 1

HCID 11517478HCID 11517478, compound

Procedure

A sample of 1-{4-[4-(4-hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone hydrochloride was prepared from compound 1-(2-chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol (0.3 g, 1.04 mmol) and 1-(4-amino-phenyl)-ethanone (0.14 g, 1.04 mmol) according to a procedure analogous to that described above in Example 48.

Sources & evidence

ORD record
ord-3d74bfc65eaa421e9ee2701339a442b6
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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