3-Chloro-4-methoxyaniline → HCID 178492210, compound

HRID 1161678Notes

Reaction equation

HRID 1161678 reaction equation
C(S[C:4]1[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=1)C.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:26])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]>C1(OC2C=CC=CC=2)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([NH:26][C:4]2[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:5]=2)[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]

Participants

4

Reactant 2

HCID 214413-Chloro-4-methoxyanilineHCID 178477357HCID 178477357, compound

Product 1

HCID 178492210HCID 178492210, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

2-Ethylsulfanyl-6-phenyl-pyrimidin-4-ol (3.0 g, 12.8 mmol) was treated with 3-chloro-4-methoxy-phenylamine (2.0 g, 12.8 mmol) in diphenyl ether at 180° C. for 16 hours to give 2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-ol.

Sources & evidence

ORD record
ord-cc87bfdbcd4c4de1aec82ad78b8115ee
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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