Phosphorus oxychloride → HCID 58626069, compound

HRID 1161679Notes

Reaction equation

HRID 1161679 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15](O)[CH:14]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O=P(Cl)(Cl)[Cl:26]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([Cl:26])[CH:14]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178492210HCID 178492210, compound

Product 1

HCID 58626069HCID 58626069, compound

Procedure

Chlorination of 2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-ol (1.5 g, 4.1 mmol) with POCl3 (10 mL) as explained above, afforded (3-chloro-4-methoxy-phenyl)-(4-chloro-6-phenyl-pyrimidin-2-yl)-amine.

Sources & evidence

ORD record
ord-fb53c273d43841c484be5986842f94c7
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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