Potassium Carbonate → HCID 58626080, compound

HRID 1161684Notes

Reaction equation

HRID 1161684 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[F:10][C:11]([F:21])([F:20])[O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:17][C:16]2[CH:18]=[CH:19][C:13]([O:12][C:11]([F:10])([F:20])[F:21])=[CH:14][CH:15]=2)[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 773782,4,6-TrichloropyrimidineHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 58626080HCID 58626080, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of compound 2,4,6-trichloro-pyrimidine (1 g, 5.63 mmol), 4-trifluromethoxy aniline (1.99 g, 11.24 mmol) and K2CO3 (0.7 g, 6.60 mmol) in 20 mL of ethanol was stirred at room temperature for 15 hours under nitrogen atmosphere. Ethanol was then removed under reduced pressure and water was added. The solid obtained was filtered and dried under vacuum to afford the compound (2,6-dichloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine (1.7 g, 96%) as a white solid.

Workup

  1. customEthanol was then removed under reduced pressure and water
  2. additionwas added
  3. customThe solid obtained
  4. filtrationwas filtered
  5. customdried under vacuum

Sources & evidence

ORD record
ord-22eb529033174ca8a15e1a27c3fdca65
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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