3-Chloro-4-methoxyaniline → 4-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylamino]-cyclohexanol

HRID 1161699Notes

Reaction equation

HRID 1161699 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([NH:14][CH:15]2[CH2:20][CH2:19][CH:18]([OH:21])[CH2:17][CH2:16]2)[N:3]=1.[Cl:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[NH2:26]>C(O)CCC>[Cl:22][C:23]1[CH:24]=[C:25]([NH:26][C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:5]=[C:4]([NH:14][CH:15]3[CH2:20][CH2:19][CH:18]([OH:21])[CH2:17][CH2:16]3)[N:3]=2)[CH:27]=[CH:28][C:29]=1[O:30][CH3:31]

Participants

4

Reactant 2

HCID 214413-Chloro-4-methoxyanilineHCID 58626065HCID 58626065, compound

Product 1

HCID 115101234-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylamino]-cyclohexanolYield 53%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

4-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylamino]-cyclohexanol was prepared by reacting compound 4-(4-chloro-6-phenyl-pyrimidin-2-ylamino)-cyclohexanol (0.15 g, 0.49 mmol) with 3-chloro-4-methoxyaniline (85 mg, 0.54 mmol) in 1-butanol according to the procedure described above. Yield: 53%.

Sources & evidence

ORD record
ord-8d9f20c7eff848df8ddbfac48ff064d9
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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