1-Ethylpiperazine → HCID 11539088, compound

HRID 1161700Notes

Reaction equation

HRID 1161700 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15](Cl)[CH:14]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH2:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[CH3:25]>C(O)CCC>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([N:29]3[CH2:30][CH2:31][N:26]([CH2:24][CH3:25])[CH2:27][CH2:28]3)[CH:14]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 791961-EthylpiperazineHCID 58626069HCID 58626069, compound

Product 1

HCID 11539088HCID 11539088, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The title compound was prepared by treating (3-chloro-4-methoxy-phenyl)-(4-chloro-6-phenyl-pyrimidin-2-yl)-amine (0.5 g, 1.4 mmol) with N-ethyl piperazine (0.16 g, 1.4 mmol) in n-butanol at refluxing temperature.

Workup

  1. temperatureat refluxing temperature

Sources & evidence

ORD record
ord-663dd4ed40424ce290f3d4ffcb5eddd2
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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