1-Butanol → HCID 11539088, compound

HRID 1161701Notes

Reaction equation

HRID 1161701 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15](Cl)[CH:14]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.[CH2:31](O)CCC>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:16]=[C:15]([N:28]3[CH2:29][CH2:30][N:25]([CH2:24][CH3:31])[CH2:26][CH2:27]3)[CH:14]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 531671-MethylpiperazineHCID 58626069HCID 58626069, compound

Product 1

HCID 11539088HCID 11539088, compound

Procedure

The title compound was prepared by treating (3-chloro-4-methoxy-phenyl)-(4-chloro-6-phenyl-pyrimidin-2-yl)-amine (0.5 g, 1.4 mmol) with N-methyl piperazine in n-butanol at refluxing temperature.

Workup

  1. temperatureat refluxing temperature

Sources & evidence

ORD record
ord-1d3c963f68ba45569b53c4385291ba46
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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