4-(Methylthio)aniline → (2,6-Diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine

HRID 1161706Notes

Reaction equation

HRID 1161706 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[CH3:20][S:21][C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1>C(O)CCC>[C:14]1([C:4]2[N:3]=[C:2]([NH:28][C:25]3[CH:26]=[CH:27][C:22]([S:21][CH3:20])=[CH:23][CH:24]=3)[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:5]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 660384-(Methylthio)anilineHCID 5820414-Chloro-2,6-diphenylpyrimidine

Product 1

HCID 58626107(2,6-Diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

4-Chloro-2,6-diphenyl-pyrimidine (0.4 g, 1.5 mmol) was reacted with 4-methylsulfanyl-phenylamine (0.22 g, 1.6 mmol) in a solvent n-butanol (10 mL) at reflux temperature for 12 hours to yield (2,6-diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine.

Workup

  1. temperatureat reflux temperature for 12 hours

Sources & evidence

ORD record
ord-c17725e9f24e47b3a2331d7d3e489e4b
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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