Propan-2-one--water (1/1) → (2,6-Diphenyl-pyrimidin-4-yl)-(4-methanesulfonyl-phenyl)-amine

HRID 1161707Notes

Reaction equation

HRID 1161707 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17](SC)=[CH:16][CH:15]=3)[CH:10]=[C:9]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[O:29][S:30]([O-:32])=O.[K+].[CH3:34]C(C)=O.O>>[C:1]1([C:7]2[N:12]=[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([S:30]([CH3:34])(=[O:32])=[O:29])=[CH:16][CH:15]=3)[CH:10]=[C:9]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 18366337Propan-2-one--water (1/1)HCID 23707502Potassium hydroxy sulfiteHCID 58626107(2,6-Diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine

Product 1

HCID 58626171(2,6-Diphenyl-pyrimidin-4-yl)-(4-methanesulfonyl-phenyl)-amine

Procedure

(2,6-Diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine (0.17 g, 0.46 mmol) was oxidized with oxone (0.84 g, 1.3 mmol) in acetone-water (2:1, 9 mL) at room temperature for 5 minutes. Solid was filtered and dried.

Workup

  1. filtrationSolid was filtered
  2. customdried

Sources & evidence

ORD record
ord-02c2c8a6ef704c328a7a089bebd0bdfd
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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