Propan-2-one--water (1/1) → HCID 58626100, compound

HRID 1161708Notes

Reaction equation

HRID 1161708 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([NH:14][C:15]2[CH:20]=[CH:19][C:18](SC)=[CH:17][CH:16]=2)[CH:3]=1.O[O:24][S:25]([O-:27])=O.[K+].[CH3:29]C(C)=O.O>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:5]=[C:4]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([S:25]([CH3:29])(=[O:27])=[O:24])=[CH:17][CH:16]=2)[CH:3]=1

Participants

4

Reactant 3

HCID 18366337Propan-2-one--water (1/1)HCID 23707502Potassium hydroxy sulfiteHCID 58626075HCID 58626075, compound

Product 1

HCID 58626100HCID 58626100, compound

Procedure

(6-Chloro-2-phenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine (1 g, 3.03 mmol) was treated with oxone in acetone-water at temperature in the range of 20-40° C. for 1 hour to yield the desired compound.

Sources & evidence

ORD record
ord-0ec23fb2f709411395142421ac37e96c
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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