Morpholine → HCID 58626073, compound

HRID 1161716Notes

Reaction equation

HRID 1161716 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:9]=2)[N:5]=[C:4]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=2)[N:3]=1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>C(O)CCC>[CH3:17][S:14]([C:10]1[CH:9]=[C:8]([C:6]2[CH:7]=[C:2]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[N:3]=[C:4]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=3)[N:5]=2)[CH:13]=[CH:12][CH:11]=1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 58626111HCID 58626111, compound

Product 1

HCID 58626073HCID 58626073, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

[4-Chloro-6-(3-methanesulfonyl-phenyl)-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine (0.14 g, 0.3 mmol) was reacted with morpholine (0.09 mL) in a solvent n-butanol (7 mL) at reflux temperature for 12 hours. Solid was filtered and dried to afford the desired compound.

Workup

  1. temperatureat reflux temperature for 12 hours
  2. filtrationSolid was filtered
  3. customdried

Sources & evidence

ORD record
ord-68e1c68e7051499084111d69bcc8e80a
Source dataset
uspto-grants-2010_10
Patent number
US07820654B2

Reaction notes

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