反应详情

温度

100 °C

Aqueous potassium phosphate was added to a suspension of 2,4-dimethylbenzene boronic acid and 2-amino-4,6-dichloro-5-pyrimidinecarbaldehyde (3 eq) in 1,4-dioxan, under a nitrogen atmosphere. Dichloro bis(triphenylphosphine)palladium (II) (cat.) was added and the mixture heated, ˜100° C., for ˜90 mins. The resulting mixture was allowed to cool and dichloromethane added, the mixture was washed with water and saturated aqueous sodium chloride solution. The solution was dried over anhydrous sodium sulphate and concentrated to a pale yellow solid. The crude solid was purified by column chromatography on silica eluting with mixtures of diethyl ether and hexane.

1. temperatureto cool
2. washthe mixture was washed with water and saturated aqueous sodium chloride solution
3. dry with materialThe solution was dried over anhydrous sodium sulphate
4. concentrationconcentrated to a pale yellow solid
5. customThe crude solid was purified by column chromatography on silica eluting with mixtures of diethyl ether and hexane