HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 58136204, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Ammonium Bicarbonate | HCID 14013 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | HCID 11708768 | HCID 11708768 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58136204 | HCID 58136204 | — |
Reaction Steps
A stirred solution of (4S)-1-[(Benzyloxy)carbonyl]-4-fluoro-L-proline in dioxane was treated with pyridine (0.7 eq.) and Boc2O (1.3 eq.), then ammonium bicarbonate (1.26 eq.) was added and the mixture was stirred at room temperature for 15 hours. Dioxane was concentrated and the residue was taken up in ethyl acetate, washed with 1 N HCl and brine, dried over Na2SO4 to give, after filtration and concentration, title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820660B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-0acffb2e24d5473bb23f9bd758dc271c |
| Source note | uspto-grants-2010_10 |