HCID 58786867, compound → HCID 21098182, compound

HRID 1161945Notes

Reaction equation

HRID 1161945 reaction equation
[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:21][CH2:20][N:19]2C(OCC2C=CC=CC=2)=O)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:29])([CH3:30])[CH3:28])=[O:25])[CH2:21][CH2:20][NH:19]2)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 58786867HCID 58786867, compound

Product 1

HCID 21098182HCID 21098182, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 23938PalladiumSolvent

Procedure

1-Benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-2-methylpiperazine-1,4-dicarboxylate was dissolved in AcOEt (20 ml/mmol) and hydrogenated at atm pressure on 10% (w/w) Pd/C over night. After filtration of the catalyst, solvent was evaporated to give crude product.

Workup

  1. filtrationAfter filtration of the catalyst, solvent
  2. customwas evaporated
  3. customto give crude product

Sources & evidence

ORD record
ord-5f8cd3c13ce74b7a8a624a39b910f233
Source dataset
uspto-grants-2010_10
Patent number
US07820660B2

Reaction notes

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