HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 66893941 | HCID 66893941 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine | HCID 86058078 | — |
Reaction Steps
(2-Morpholin-4-ylethyl)(5-nitro-1-benzofuran-7-yl)amine (450 mg, 1.545 mmol; Intermediate 27) was dissolved in THF (5 mL). After addition of ethanol (100 mL), Raney-nickel (cat.) and hydrazine hydrate (2 mL), the mixture was left stirring at room temperature for 2 h. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820675B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-0f165c00b7cd496896c1e4dd1ff174f4 |
| Source note | uspto-grants-2010_10 |