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HRID1162002

反应详情

EQUATION

反应方程式

HRID 1162002 的结构方程式

REACTANTS

反应物

4
结构：c1cnc2c(c1)ccc1cccnc12
HCID1318

1,10-Phenanthroline

C12H8N2

结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：OCCN1CCOCC1
HCID61163

4-(2-Hydroxyethyl)morpholine

C6H13NO2

结构：O=[N+]([O-])c1cc(I)c2occc2c1
HCID21864764

未命名化合物

PRODUCTS

生成物

1
结构：O=[N+]([O-])c1cc(OCCN2CCOCC2)c2occc2c1
HCID66893394

未命名化合物

收率 32%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

To a test tube was added 7-iodo-5-nitrobenzofuran (1.0 g, 0.00346 mol), 4-(2-hydroxyethyl)morpholine (0.91 g, 0.00692 mol), cesium carbonate (2.25 g, 0.00692 mol), 1,10-phenanthroline (0.25 g, 0.00138 mol) and CuI (130 mg, 0.692 mmol). Toluene (15 mL) was added and the solution was heated in a StemBlock for 72 h. After filtration through Celite, the crude material was purified by flash chromatography (EtOAc/DCM; 1:1). Yield: 32%, HPLC purity=90%, m/z=293 (M+H)+.

WORKUP

后处理

  1. temperaturethe solution was heated in a StemBlock for 72 h
  2. filtrationAfter filtration through Celite
  3. customthe crude material was purified by flash chromatography (EtOAc/DCM; 1:1)