{[(2R)-1-Ethylpyrrolidin-2-yl]methyl}(5-nitro-1-benzofuran-7-yl)amine → N7-{[(2R)-1-Ethylpyrrolidin-2-yl]methyl}-1-benzofuran-5,7-diamine

HRID 1162014Notes

Reaction equation

HRID 1162014 reaction equation
N1(CCNC2C3OC=CC=3C=C(N)C=2)CCOCC1.[CH2:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@@H:23]1[CH2:27][NH:28][C:29]1[C:37]2[O:36][CH:35]=[CH:34][C:33]=2[CH:32]=[C:31]([N+:38]([O-])=O)[CH:30]=1)[CH3:21]>>[CH2:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@@H:23]1[CH2:27][NH:28][C:29]1[C:37]2[O:36][CH:35]=[CH:34][C:33]=2[CH:32]=[C:31]([NH2:38])[CH:30]=1)[CH3:21]

Participants

3

Reactant 2

HCID 66893445{[(2R)-1-Ethylpyrrolidin-2-yl]methyl}(5-nitro-1-benzofuran-7-yl)amine2×HCID 86058078N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

Product 1

HCID 86609635N7-{[(2R)-1-Ethylpyrrolidin-2-yl]methyl}-1-benzofuran-5,7-diamine

Procedure

The title compound was prepared according to the procedure described for Intermediate 28 using {[(2R)-1-ethylpyrrolidin-2-yl]methyl}(5-nitro-1-benzofuran-7-yl)amine (Intermediate 37). The obtained product was used directly in the subsequent reaction.

Workup

  1. customThe obtained product was used directly in the subsequent reaction

Sources & evidence

ORD record
ord-f64d002371ad4594be2a520046bdf413
Source dataset
uspto-grants-2010_10
Patent number
US07820675B2

Reaction notes

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