HCID 66893263, compound → HCID 66891956, compound

HRID 1162077Notes

Reaction equation

HRID 1162077 reaction equation
COC1C=CC(C)=CC=1S(C1C=C(C(OC)=O)C2OC=CC=2C=1)(=O)=O.[CH3:26][C:27]1[CH:32]=[CH:31][C:30]([S:33]([C:36]2[CH:37]=[C:38]([C:45]([O:47][CH3:48])=[O:46])[C:39]3[O:43][CH2:42][CH2:41][C:40]=3[CH:44]=2)(=[O:35])=[O:34])=[CH:29][CH:28]=1>>[CH3:26][C:27]1[CH:28]=[CH:29][C:30]([S:33]([C:36]2[CH:37]=[C:38]([C:45]([O:47][CH3:48])=[O:46])[C:39]3[O:43][CH:42]=[CH:41][C:40]=3[CH:44]=2)(=[O:35])=[O:34])=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 66893263HCID 66893263, compoundHCID 66893431HCID 66893431, compound

Product 1

HCID 66891956HCID 66891956, compound

Procedure

The title compound was prepared according to the procedure of Intermediate 67 starting from methyl 5-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1-benzofuran-7-carboxylate (117 mg, 0.4 mmol; obtained in Step 1). Yield: 62 mg (53%) after purification by preparative HPLC (System F; 40-60% MeCN). MS (ESI+) for C17H16O5S m/z 331 (M+H)+.

Workup

  1. customYield: 62 mg (53%) after purification by preparative HPLC (System F; 40-60% MeCN)

Sources & evidence

ORD record
ord-04de6e1739f24c67893cb1c907c8c1de
Source dataset
uspto-grants-2010_10
Patent number
US07820675B2

Reaction notes

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