HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N,N-Dimethyl-1,3-propanediamine → N1-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-N3,N3-dimethylpropane-1,3-diamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| Edukt | 3-Bromo-6-chloroimidazo(1,2-b)pyridazine | HCID 12872323 | — |
| Edukt | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| Produkt | N1-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-N3,N3-dimethylpropane-1,3-diamine | HCID 68648083 | — |
Reaktionsschritte
Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and N1,N1-dimethylpropane-1,3-diamine according to general procedure 1 providing the intermediate (160 mg, 84%) as a clear oil: Rf=0.16 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CD3OD) δ 7.54 (d, J=9.5 Hz, 1H), 7.39 (s, 1H), 6.68 (d, J=9.5 Hz, 1H), 3.40 (t, J=7.1 Hz, 2H), 2.48-2.45 (m, 2H), 2.27 (s, 6H), 1.93-1.88 (m, 2H); ES-MS: (M+H)=298, 300 m/z.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07820670B2 |
| Quelldatensatz | uspto-grants-2010_10 |
| ORD ID | ord-1ef286054fc54a9488e909d5f917c8c8 |
| Quellennotiz | uspto-grants-2010_10 |