2-(Aminomethyl)-5-methylpyrazine → HCID 68648262, compound

HRID 1162135Notes

Reaction equation

HRID 1162135 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[CH3:12][C:13]1[N:14]=[CH:15][C:16]([CH2:19][NH2:20])=[N:17][CH:18]=1.C(Cl)Cl.CO.[NH4+].[OH-]>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:20][CH2:19][C:16]3[CH:15]=[N:14][C:13]([CH3:12])=[CH:18][N:17]=3)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

Participants

4

Reactant 3

HCID 27564962-(Aminomethyl)-5-methylpyrazineHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 21896990Dichloromethane methanol ammonium hydroxide

Product 1

HCID 68648262HCID 68648262, compound

Procedure

Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and (5-methylpyrazin-2-yl)methanamine according to general procedure 1 providing the intermediate (64 mg, 34%) as a yellow solid: Rf=0.67 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CD3OD) δ 8.69 (s, 1H), 8.47 (s, 1H), 7.60 (d, J=9.7 Hz, 1H), 7.39 (s, 1H), 6.79 (d, J=9.7 Hz, 1H), 4.66 (s, 2H), 2.53 (s, 3H); ES-MS: (M+H)=319, 321 m/z.

Sources & evidence

ORD record
ord-d7d49a944a3f4fa0b14cece5389870e4
Source dataset
uspto-grants-2010_10
Patent number
US07820670B2

Reaction notes

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