4-Dimethylaminobutylamine → N1-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-N4,N4-dimethylbutane-1,4-diamine

HRID 1162139노트

반응식

HRID 1162139 반응식
[Br:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[CH3:12][N:13]([CH3:19])[CH2:14][CH2:15][CH2:16][CH2:17][NH2:18].C(Cl)Cl.CO.[NH4+].[OH-]>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:18][CH2:17][CH2:16][CH2:15][CH2:14][N:13]([CH3:19])[CH3:12])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

참가 물질

4

반응물 3

HCID 770634-DimethylaminobutylamineHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 21896990Dichloromethane methanol ammonium hydroxide

생성물 1

HCID 68648035N1-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-N4,N4-dimethylbutane-1,4-diamine

실험 절차

Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and N1,N1-dimethylbutane-1,4-diamine according to general procedure 1 providing the intermediate (300 mg, 74%) as a yellow oil: Rf=0.40 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CDCl3) δ 7.53 (d, J=9.6 Hz, 1H), 7.45 (s, 1H), 6.38 (d, J=9.6 Hz, 1H), 6.07 (brs, 1H), 3.40 (quart, J=5.2 Hz, 2H), 2.34 (t, J=6.8 Hz, 2H), 2.25 (s, 6H), 1.76 (quin, J=6.6 Hz, 2H), 1.64 (quin, J=6.8 Hz, 2H); ES-MS: (M+H)=312, 314 m/z.

출처 및 근거

ORD 기록
ord-bdc63573c5e74a2690c89e91fdcedf29
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820670B2

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