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HRID 1162139作成日：2026年10月25日

4-Dimethylaminobutylamine → N1-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-N4,N4-dimethylbutane-1,4-diamine

https://huagongshe.com/reaction/1162139

反応式

関与物質

役割名称HCID仕込み量
反応物4-DimethylaminobutylamineHCID 77063—
反応物3-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 12872323—
反応物Dichloromethane methanol ammonium hydroxideHCID 21896990—
生成物N1-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)-N4,N4-dimethylbutane-1,4-diamineHCID 68648035—

反応手順

Prepared from 3-bromo-6-chloroimidazo[1,2-b]pyridazine and N1,N1-dimethylbutane-1,4-diamine according to general procedure 1 providing the intermediate (300 mg, 74%) as a yellow oil: Rf=0.40 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CDCl3) δ 7.53 (d, J=9.6 Hz, 1H), 7.45 (s, 1H), 6.38 (d, J=9.6 Hz, 1H), 6.07 (brs, 1H), 3.40 (quart, J=5.2 Hz, 2H), 2.34 (t, J=6.8 Hz, 2H), 2.25 (s, 6H), 1.76 (quin, J=6.6 Hz, 2H), 1.64 (quin, J=6.8 Hz, 2H); ES-MS: (M+H)=312, 314 m/z.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07820670B2
出典データセットuspto-grants-2010_10
ORD IDord-bdc63573c5e74a2690c89e91fdcedf29
出典メモuspto-grants-2010_10