反应详情

A solution of sodium sulfite (12.6 g, 0.1 mol) in water (180 mL) was heated to 70-75° C. under stirring, and the acetic acid 1-acetyl-1H-indol-3-yl ester of Example 1c (9.0 g, 0.041 mol) was added in small portions. The mixture was stirred at 70-75° C. for 1.5 h, and then kept at room temperature overnight. The solid product was filtered off, dried, dissolved in methylene chloride (40 mL) and flash-chromatographed on aluminum oxide with methylene chloride as an eluent to give 5.25 g (71%) of light yellow product; m.p. 138° C.

1. stirringThe mixture was stirred at 70-75° C. for 1.5 h
2. filtrationThe solid product was filtered off
3. customdried
4. dissolutiondissolved in methylene chloride (40 mL)
5. customflash-chromatographed on aluminum oxide with methylene chloride as an eluent