HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+)-Methyl lactate → methyl (2S)-2-[(4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+)-Methyl lactate | HCID 637514 | — |
| Reactant | 5-fluoro-N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]quinazolin-4-amine | HCID 68619430 | — |
| Product | methyl (2S)-2-[(4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate | HCID 86627836 | — |
Reaction Steps
The 5-fluoro-N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]quinazolin-4-amine (2.4 g, 6.48 mmol) was reacted as in Example 5 starting material, except that (R)-methyl lactate was used instead of (s)-methyl lactate, to give methyl (2S)-2-[(4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}quinazolin-5-yl)oxy]propanoate:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820683B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-e8a650070c774af59495d88ee9ebe856 |
| Source note | uspto-grants-2010_10 |