Sodium Hydroxide → HCID 58840902, compound

HRID 1162287Notes

Reaction equation

HRID 1162287 reaction equation
C[O:2][C:3](=[O:22])[CH:4]([O:11][C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[OH-].[Na+]>CO.C1COCC1>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C:12]([O:11][CH:4]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:3]([OH:22])=[O:2])=[O:13])=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86612126HCID 86612126, compound

Product 1

HCID 58840902HCID 58840902, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Methyl((((4-chlorophenyl)amino)carbonyl)oxy)(phenyl)acetate (0.73 g) obtained in Example 3a) and 1 N sodium hydroxide (3.0 ml) were dissolved in methanol (10 ml) and THF (10 ml), and then mixed at room temperature for 15 hours. The reaction solution was then concentrated under reduced pressure, acidified by adding 1 N hydrochloric acid to the concentrated solution, and then the precipitate was collected by filtration and washed with water to obtain the title compound as pale brown powder (0.62 g, 89%).

Workup

  1. concentrationThe reaction solution was then concentrated under reduced pressure
  2. additionby adding 1 N hydrochloric acid to the concentrated solution
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-786dfc72404a4c80b489fbbe08235b99
Source dataset
uspto-grants-2010_10
Patent number
US07820673B2

Reaction notes

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