Potassium Cyanide → HCID 23138192, compound

Ammonium chloride (2.9 g) and potassium cyanide (3.3 g) were dissolved in water (20 ml), a solution of 3-methoxy-2,2-dimethylpropanal (F. Effenberger et al., Tetrahedron: Asymmetry, 6, 271-282 (1995); 5.7 g) in aqueous ammonia (5 ml) was added dropwise at 0° C., and mixed at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with diluted hydrochloric acid. The aqueous solution was washed with diethyl ether, alkalified with a 1 N aqueous sodium hydroxide solution and extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain the title compound as a pale yellow oil (0.57 g, 8%).

1. additionmixed at room temperature for 3 days
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionthe residue was diluted with diluted hydrochloric acid
4. washThe aqueous solution was washed with diethyl ether
5. extractionextracted with dichloromethane
6. dry with materialThe extract was dried over anhydrous magnesium sulfate
7. distillationthe solvent was distilled off under reduced pressure

ORD record

ord-63785958f4da4e69bbe66b723b976a04

Source dataset

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07820673B2