HCID 23084287, compound → HCID 23138299, compound

HRID 1162323Notes

Reaction equation

HRID 1162323 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][C:17]3=[CH:19][N:20]=[C:21]([CH2:22][O:23][Si:24]([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25])[N:16]3[C:15]2=[O:31])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[Si:24]([O:23][CH2:22][C:21]1[N:16]2[C:15](=[O:31])[N:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH2:18][C:17]2=[CH:19][N:20]=1)([C:27]([CH3:28])([CH3:29])[CH3:30])([CH3:26])[CH3:25]

Participants

4

Reactant 1

HCID 23084287HCID 23084287, compound

Product 1

HCID 23138299HCID 23138299, compoundYield 111.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

2-(1-Benzyl-4-piperidinyl)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one (0.18 g) obtained in Example 83h) and 10% palladium carbon (36 mg) were suspended in methanol (3 ml), and mixed under hydrogen atmosphere at room temperature for 18 hours. The reaction solution was filtered using Celite, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless solid (0.16 g, quantitative).

Workup

  1. additionmixed under hydrogen atmosphere at room temperature for 18 hours
  2. filtrationThe reaction solution was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-72fa94f16f9d4799b5b70f9a1e3f30a0
Source dataset
uspto-grants-2010_10
Patent number
US07820673B2

Reaction notes

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