Hydrochloric Acid → HCID 23138420, compound

HRID 1162348Notes

Reaction equation

HRID 1162348 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH2:20][C:19]3=[CH:21][N:22]=[C:23]([CH3:24])[N:18]3[C:17]2=[O:25])[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl>[C].[Pd].CO>[CH3:24][C:23]1[N:18]2[C:17](=[O:25])[N:16]([CH2:15][CH2:14][N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH2:20][C:19]2=[CH:21][N:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23138248HCID 23138248, compound

Product 1

HCID 23138420HCID 23138420, compoundYield 63%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

2-(2-(1-Benzyl-4-piperazinyl)ethyl)-5-methyl-1,2-dihydroimidazo[1,5-c]imidazol-3-one (0.22 g) obtained in Example 97b), 1 N hydrochloric acid (1 ml) and 10% palladium carbon (74 mg) were added to methanol (10 ml), and mixed under hydrogen atmosphere at room temperature for 3 days. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was dissolved in a small amount of water, and the reaction mixture was basified with potassium carbonate and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain the title compound (0.10 g, 63%).

Workup

  1. additionmixed under hydrogen atmosphere at room temperature for 3 days
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. dissolutionThe residue was dissolved in a small amount of water
  5. extractionextracted with ethyl acetate
  6. dry with materialThe extract was dried over anhydrous magnesium sulfate
  7. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-e3078bb826e44ab4bb069fbf74e0fc61
Source dataset
uspto-grants-2010_10
Patent number
US07820673B2

Reaction notes

Loading…