HCID 90738539, compound → HCID 68646741, compound

HRID 1162352Notes

Reaction equation

HRID 1162352 reaction equation
[CH3:1][C:2]([CH3:32])([CH3:31])[C@@H:3]([NH:20]C(=O)OCC1C=CC=CC=1)[C:4]([N:6]1[CH2:11][CH2:10][CH:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][C:13]2=[O:19])[CH2:8][CH2:7]1)=[O:5]>C(O)C.[C].[Pd]>[NH2:20][C@H:3]([C:2]([CH3:32])([CH3:31])[CH3:1])[C:4]([N:6]1[CH2:11][CH2:10][CH:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][C:13]2=[O:19])[CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 1

HCID 90738539HCID 90738539, compound

Product 1

HCID 68646741HCID 68646741, compoundYield 95.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Benzyl(1R)-2,2-dimethyl-1-((4-(4-methyl-2-oxo-1-piperazinyl)-1-piperidinyl)carbonyl)propylcarbamate (0.18 g) obtained in Example 103c) was dissolved in ethanol (10 ml), 10% palladium carbon (50% water content; 20 mg) was added thereto, and mixed under hydrogen atmosphere at room temperature for 2 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless oil (0.12 g, 91%).

Workup

  1. additionmixed under hydrogen atmosphere at room temperature for 2 hours
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a23b16f4661741cbb204b6b4c0a32da1
Source dataset
uspto-grants-2010_10
Patent number
US07820673B2

Reaction notes

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