Piperidine → 5-Bromo-2-(piperidin-1-yl)benzonitrile

HRID 1162405Notes

Reaction equation

HRID 1162405 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CS(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 10796Cesium carbonateHCID 27249005-Bromo-2-fluorobenzonitrile

Product 1

HCID 669954185-Bromo-2-(piperidin-1-yl)benzonitrile

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

5-Bromo-2-fluorobenzonitrile and piperidine were heated at 80° C. in DMSO in the presence of cesium carbonate to obtain 5-bromo-2-piperidin-1-ylbenzonitrile. F: 265.

Sources & evidence

ORD record
ord-bb66220175c1475db9d91999b9932cb9
Source dataset
uspto-grants-2010_10
Patent number
US07820700B2

Reaction notes

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