Thiourea → 4-(4-Isopropyl-phenyl)-thiazol-2-ylamine

HRID 1162538Notes

Reaction equation

HRID 1162538 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:13])[CH3:12])=[CH:7][CH:6]=1)=O.[NH2:14][C:15]([NH2:17])=[S:16]>CO>[CH:11]([C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:14]=[C:15]([NH2:17])[S:16][CH:2]=2)=[CH:6][CH:7]=1)([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 140427562-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one

Product 1

HCID 6736934-(4-Isopropyl-phenyl)-thiazol-2-ylamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(4-Isopropyl-phenyl)-thiazol-2-ylamine was prepared (0.41 g) following general procedure B using 2-bromo-1-(4-isopropyl-phenyl)-ethanone (0.5 g, 2.07 mmol), thiourea (173 mg, 2.28 mmol) and MeOH (10 mL). LCMS m/z: 219 (M+1)+.

Sources & evidence

ORD record
ord-a8dfa7fcbed24e7e957d38e0de9d1715
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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