4-(4-Isopropyl-phenyl)-thiazol-2-ylamine → HCID 59520223, compound

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Isopropyl-phenyl)-thiazol-2-ylamine	HCID 673693	—
Reactant	Tert-butyl 2-(chlorosulfonyl)acetate	HCID 43350783	—
Catalyst	4-(Dimethylamino)pyridine	HCID 14284	—
Product	HCID 59520223	HCID 59520223	—

Reaction Steps

4-(4-Isopropyl-phenyl)-thiazol-2-ylamine, chlorosulfonyl-acetic acid tert-butyl ester, DMAP (10 mol %) were combined using general procedure C (method 2) to afford [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester. LCMS m/z: 398 (M+1)+; 1H NMR (CDCl3, 400 MHz): δ 1.27 (d, 6H); 1.44 (s, 9H); 2.95 (m, 1H); 4.06 (s, 2H); 6.48 (s, 1H); 7.32 (d, 2H); 7.39 (d, 2H); 10.5 (brs, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07820704B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-1e88d6f846e54386b4c63f9618910881
Source note	uspto-grants-2010_10