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HRID1162541

反应详情

EQUATION

反应方程式

HRID 1162541 的结构方程式

REACTANTS

反应物

2
结构：CC(C)c1ccc(-c2csc(N)n2)cc1
HCID673693

4-(4-Isopropyl-phenyl)-thiazol-2-ylamine

C12H14N2S

结构：CC(C)(C)OC(=O)CS(=O)(=O)Cl
HCID43350783

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)c1ccc(-c2csc(NS(=O)(=O)CC(=O)OC(C)(C)C)n2)cc1
HCID59520223

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

4-(4-Isopropyl-phenyl)-thiazol-2-ylamine, chlorosulfonyl-acetic acid tert-butyl ester, DMAP (10 mol %) were combined using general procedure C (method 2) to afford [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester. LCMS m/z: 398 (M+1)+; 1H NMR (CDCl3, 400 MHz): δ 1.27 (d, 6H); 1.44 (s, 9H); 2.95 (m, 1H); 4.06 (s, 2H); 6.48 (s, 1H); 7.32 (d, 2H); 7.39 (d, 2H); 10.5 (brs, 1H).