Hydrochloric Acid → HCID 68647955, compound

HRID 1162574Notes

Reaction equation

C[O:2][C:3](=[O:37])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)=[CH:25][CH:24]=3)[N:18]=2)[CH:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:5]=1.[ClH:38]>>[ClH:38].[CH:31]1([CH2:30][O:29][C:26]2[CH:25]=[CH:24][C:23]([C:19]3[N:18]=[C:17]([N:11]([CH2:10][C:6]4[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=4)[C:3]([OH:37])=[O:2])[CH:12]4[CH2:13][CH2:14][CH2:15][CH2:16]4)[CH:22]=[CH:21][N:20]=3)=[CH:28][CH:27]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68648418HCID 68648418, compound

Product 1

HCID 68647955HCID 68647955, compound

Procedure

This product was hydrolyzed according to general procedure T. The 3-({[2-(4-cyclohexylmethoxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amino}-methyl)-benzoic acid produced was then converted to its corresponding HCl salt following general procedure G2 to give 3-({[2-(4-cyclohexylmethoxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amino}methyl)-benzoic acid hydrochloride (22 mg). LCMS m/z: 487 (M+1)+.

Sources & evidence

ORD record: ord-8419d4cd4dce45b5a9cec601542f083c
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820704B2

Reaction notes

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