Ammonium Chloride → HCID 178438899, compound

HRID 1162578Notes

Reaction equation

HRID 1162578 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([N:15]([CH2:22][C:23]3[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=3[C:25]#[N:26])[CH2:16][C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[Cl-].[NH4+].[N-:33]=[N+:34]=[N-:35].[Na+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[C:12]([N:15]([CH2:22][C:23]3[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=3[C:25]3[NH:35][N:34]=[N:33][N:26]=3)[CH2:16][C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[S:13][CH:14]=2)=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 68647686HCID 68647686, compound

Product 1

HCID 178438899HCID 178438899, compoundYield 4.1%

Procedure

[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-[2-(1H-tetrazol-5-yl)-benzyl]-thiophen-2-ylmethyl-amine (6.0 mg) was prepared following general procedure H from the corresponding nitrile (130 mg, 0.31 mmol), ammonium chloride (3.1 mmol) and sodium azide (3.1 mmol). Purification (Silica gel, methanol/DCM 3:97) provided the product. LCMS m/z: 474 (M+1)+.

Workup

  1. customPurification (Silica gel, methanol/DCM 3:97)
  2. customprovided the product

Sources & evidence

ORD record
ord-65975b5577b44a2e9fca50e8be615911
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

Loading…