Hydrochloric Acid → HCID 68647929, compound

HRID 1162585Notes

Reaction equation

HRID 1162585 reaction equation
C([O:5][C:6](=[O:29])[CH2:7][N:8]([CH2:23][C:24]1[S:25][CH:26]=[CH:27][CH:28]=1)[C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[N:13]=1)(C)(C)C.[ClH:30]>O1CCOCC1>[ClH:30].[S:25]1[CH:26]=[CH:27][CH:28]=[C:24]1[CH2:23][N:8]([C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:15]=[CH:16][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:18][CH:19]=2)[N:13]=1)[CH2:7][C:6]([OH:29])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 686478282-{Thiophen-2-ylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}acetic acid tert-butyl ester

Product 1

HCID 68647929HCID 68647929, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-{Thiophen-2-ylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}acetic acid hydrochloride was prepared (63 mg) following general procedure G1 using 2-{thiophen-2-ylmethyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}acetic acid tert-butyl ester (66 mg, 0.155 mmol) and 4 N HCl solution in dioxane (1.0 mL). LCMS m/z: 474 (M+1)+.

Sources & evidence

ORD record
ord-d487e6c2d7d841e089710f7a5d416794
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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