2-Bromo-1-indanone → HCID 68648192, compound

HRID 1162586Notes

Reaction equation

HRID 1162586 reaction equation
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=O.[C:12]([O:16][C:17](=[O:30])[CH2:18][CH2:19][N:20]([CH2:24][C:25]1[S:26][CH:27]=[CH:28][CH:29]=1)[C:21]([NH2:23])=[S:22])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17](=[O:30])[CH2:18][CH2:19][N:20]([C:21]1[S:22][C:2]2[CH2:10][C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[C:3]=2[N:23]=1)[CH2:24][C:25]1[S:26][CH:27]=[CH:28][CH:29]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 1372032-Bromo-1-indanoneHCID 86601760HCID 86601760, compound

Product 1

HCID 68648192HCID 68648192, compound

Procedure

3-[(8H-Indeno[1,2-d]thiazol-2-yl)-thiophen-2-ylmethyl-amino]-propionic acid tert-butyl ester was prepared (35 mg) following general procedure B using 2-bromo-indan-1-one (22 mg, 0.1 mmol), and 3-(1-thiophen-2-ylmethyl-thioureido)-propionic acid tert-butyl ester (30 mg, 0.1 mmol). LCMS m/z: 414 (M+1)+.

Sources & evidence

ORD record
ord-99eb36c4c16a4000855b01c2a20788b2
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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