Hydrochloric Acid → HCID 68648224, compound

HRID 1162587Notes

Reaction equation

HRID 1162587 reaction equation
C([O:5][C:6](=[O:28])[CH2:7][CH2:8][N:9]([C:16]1[S:17][C:18]2[CH2:27][C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:19]=2[N:20]=1)[CH2:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)(C)(C)C.[ClH:29]>O1CCOCC1>[ClH:29].[S:17]1[C:18]2[CH2:27][C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:19]=2[N:20]=[C:16]1[N:9]([CH2:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)[CH2:8][CH2:7][C:6]([OH:28])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68648192HCID 68648192, compound

Product 1

HCID 68648224HCID 68648224, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-[(8H-Indeno[1,2-d]thiazol-2-yl)-thiophen-2-ylmethyl-amino]-propionic acid hydrochloride was prepared (32 mg) following general procedure G1 using 3-[(8H-indeno[1,2-d]thiazol-2-yl)-thiophen-2-ylmethyl-amino]-propionic acid tert-butyl ester (35 mg, 0.085 mmol) and 4 N HCl solution in dioxane (1.0 mL). LCMS m/z: 358 (M+1)+. 1H NMR (CD3OD, 400 MHz): δ 2.8 (t, 3H), 3.80 (s, 2H) 3.9 (t, 2H), 5.0 (s, 2H), 7.08 (dd, 1H), 7.21 (dd, 1H), 7.28 (t, 1H), 7.38 (t, 1H), 7.42 (dd, 1H), 7.56 (dd, 1H), 7.7 (dd, 1H).

Sources & evidence

ORD record
ord-d33f12c87fc94090a63718751f49906c
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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